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为探究不同表面电位的正极性驻极体对胰岛素降糖效果的影响,以糖尿病大鼠为动物模型,以聚丙烯(PP)薄膜为驻极体材料,通过电晕充电系统将聚丙烯制备成表面电位为500 V、1 000 V和1 500 V的驻极体。将经不同表面电位驻极体作用12 h时间后的猪胰岛素经皮下注入糖尿病大鼠体内,观察了正极性驻极体对胰岛素降糖效果的影响。研究结果显示:经正极性驻极体作用后的胰岛素的降糖效果优于无电场处理的胰岛素;正极性驻极体处理过的胰岛素的降糖效果依次为,1 000 V驻极体作用胰岛素的降糖效果优于500 V驻极体作用的胰岛素,500 V驻极体作用胰岛素的降糖效果优于1 500 V驻极体作用的胰岛素;正极性驻极体提高胰岛素的降糖效果具有“有效电压作用窗”。可得结论:合理使用正极性驻极体具有提高胰岛素的降糖效果。
In order to explore the effect of positive electrets with different surface potentials on hypoglycemic effect of insulin, the diabetic rats were used as animal model, polypropylene (PP) film was used as electret material and polypropylene was prepared by corona charging system Electret electrodes with surface potentials of 500 V, 1 000 V and 1 500 V. Porcine insulin was injected subcutaneously into the diabetic rats after being exposed to electrets with different surface potentials for 12 h, and the effect of positive electrets on the hypoglycemic effect of insulin was observed. The results showed that the hypoglycemic effect of insulin after the positive electret function was better than that of the insulin without electric field treatment. The hypoglycemic effect of the electret-treated insulin was, in turn, 1 000 V electret acting insulin Hypoglycemic effect is better than that of 500 V electret. The hypoglycemic effect of 500 V electret insulin is superior to that of 1 500 V electret. The positive electret can improve insulin hypoglycemic effect with “Effective voltage window”. Available conclusions: The rational use of positive electrets have the hypoglycemic effect of improving insulin.