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原癌基因c myc被认为是具有激活和抑制双重作用的转录调节子,在细胞的增殖、分化和凋亡过程中发挥着重要的作用。人c mycmRNA的5’-非翻译区含有一个内部核糖体进入序列(internalribosomeentrysegement ,IRES)元件。Chappell等发现c myc的IRES中一个C变为U的核苷酸替换在42 %的
The proto-oncogene c-myc is thought to be a transcriptional regulator that plays a dual role in activation and suppression and plays an important role in cell proliferation, differentiation and apoptosis. The 5’-untranslated region of human c mycmRNA contains an internal ribosome entry sequence (IRES) element. Chappell et al. Found that one C to U nucleotide substitution in the c-myc IRES was at 42%