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目的探讨急性低氧性呼吸衰竭患儿呼吸支持疗法治疗效果的影响因素,以期为临床制定科学合理的预防措施提供理论依据。方法选取2014年8月-2016年8月该院收治的150例急性低氧性呼吸衰竭患儿作为研究对象,入院后给予患儿糖皮质激素、抗生素、茶碱类及利尿剂等常规药物治疗,同时给予呼吸支持疗法治疗。统计治疗效果,对影响治疗效果的危险因素进行单因素和多因素Logistic回归分析。结果单因素分析结果显示:年龄、体质量、发病至就诊时间、经济条件、机械通气时间、急性肺损伤、重症肺炎、脓毒症、先天性心脏病、恶性疾病、中枢神经障碍、肝功能障碍、肾功能障碍及血液系统障碍是急性低氧性呼吸衰竭患儿预后效果差的影响因素(P<0.05);多因素分析结果显示:年龄≤20个月、体质量≤8 kg、发病至就诊时间>3 d、经济基础差、机械通气时间≤48 h、合并急性肺损伤、重症肺炎、脓毒症、先天性心脏病、恶性疾病、中枢神经障碍、肝功能障碍、肾功能障碍、血液系统障碍是影响急性低氧性呼吸衰竭患儿呼吸支持疗法治疗效果的危险因素(P<0.05)。结论影响急性低氧性呼吸衰竭患儿呼吸支持疗法治疗效果的危险因素较多,临床应结合危险因素,根据患儿具体情况制定合理有效的预防方案,降低发病率,提高治疗效果。
Objective To investigate the influencing factors of respiratory support therapy in children with acute hypoxemic respiratory failure and to provide a theoretical basis for making scientific and reasonable preventive measures. Methods A total of 150 children with acute hypoxemic respiratory failure admitted to our hospital from August 2014 to August 2016 were enrolled in this study. After admission, children were given conventional drug therapy such as glucocorticoids, antibiotics, theophylline and diuretics , While giving respiratory support therapy. Statistical treatment effect, the impact of treatment of risk factors by single factor and multivariate logistic regression analysis. Results The results of univariate analysis showed that age, body mass, onset to treatment time, economic conditions, mechanical ventilation time, acute lung injury, severe pneumonia, sepsis, congenital heart disease, malignant diseases, central nervous system disorders, liver dysfunction , Renal dysfunction and hematological disorders were the influential factors of poor prognosis in children with acute hypoxemic respiratory failure (P <0.05). The results of multivariate analysis showed that when the age ≤20 months, the body weight ≤8 kg, Time> 3 days, poor economic base, time of mechanical ventilation ≤ 48 h, acute lung injury complicated by severe pneumonia, sepsis, congenital heart disease, malignant diseases, central nervous system disorders, liver dysfunction, renal dysfunction, blood system Obstructions were the risk factors influencing the effect of respiratory support therapy in children with acute hypoxemic respiratory failure (P <0.05). Conclusion There are many risk factors affecting respiratory support therapy in children with acute hypoxemic respiratory failure. In combination with risk factors, reasonable and effective prevention programs should be formulated to reduce the incidence and improve the therapeutic effect.