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有研究显示,水飞蓟宾(1)的甲基化产物5′,7′,4″-三甲基水飞蓟宾(2)由于提高了脂溶性,从而增强了对佛波醇肉豆蔻酸乙酸酯(PMA)刺激的人中性白细胞中O_2~-的形成和H_2O_2释放的抑制作用。作者研究了化合物1、2、2的乙酰化产物5′,7′,4″-三甲基水飞蓟宾乙酸酯(3,脂溶性降低)和化合物1的所有羟基乙酰化产物,即全乙酰化水飞蓟宾(4)对PMA刺激的人中性白细胞蛋白激酶C(PKC)转运、还原型烟酰胺腺嘌呤二核苷酸
Studies have shown that the methylation product of silybin (1), 5′,7′,4′′-trimethylsilibinin (2), enhances fat-soluble properties and enhances phorbol myristate. Formation of O_2~- and inhibition of H_2O_2 release in human neutrophils stimulated by acid acetate (PMA).The authors studied the acetylation products 5′,7′,4′′-triple of compounds 1,2,2 Based silycin acetate (3, reduced fat-soluble) and all hydroxyl acetylated products of compound 1, namely peracetylated silybin (4) PMA-stimulated human neutrophil protein kinase C (PKC) Transported, reduced nicotinamide adenine dinucleotide