小脑顶核刺激对急性心肌梗死大鼠心率变异性的影响

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目的观察电刺激小脑顶核(FNS)对急性心肌梗死(AMI)大鼠心率变异性(HRV)的影响。方法成年雄性SD大鼠100只随机分为:AMI组(n=30),单纯结扎左冠状动脉(LCA);小脑顶核刺激(FNS)组(n=30),结扎LCA,1h后电刺激左侧小脑顶核1h;小脑顶核损毁(FNL)组(n=30),先用鹅膏氨酸毁损两侧小脑顶核,5d后再按FNS组方法操作;假手术组(n=10),开胸手术后仅在LCA下穿线但不结扎,电极插入小脑顶核,但不予刺激。各组又分开胸术后6h、1d、7d、21d4个时间点,分别采用大鼠HRV记录分析系统进行HRV频域分析。结果结扎6h,FNS组频域分析指标—低频成分明显低于AMI和FNL组(P<0.01),高频成分明显高于其他干预组(P<0.01);结扎1d后,FNS组仍然呈现高频成分的增加和低频成分的下降(P<0.05);7d后,只有假手术组保留了较高的高频功率,各干预组之间的差别消失;21d后,各组HRV参数之间无差别。FNL组与AMI组比较,各时间段HRV参数比较无显著性差异(P>0.05)。结论电刺激小脑顶核可改善AMI大鼠的HRV。 Objective To observe the effects of electrical stimulation of fastigial nucleus (FNS) on heart rate variability (HRV) in rats with acute myocardial infarction (AMI). Methods 100 adult male Sprague-Dawley rats were randomly divided into AMI group (n = 30), left coronary artery (LCA) group, fastigial nucleus stimulation group (n = 30) The left parietal fastigial nucleus 1h, FNL group (n = 30), the apical cerebellum of the two sides were destroyed with goat ointment, and the FNS group was operated 5 days later. The sham operation group (n = 10) ), Thoracotomy was performed only under LCA without ligation, and the electrode was inserted into the parietal region of the cerebellum without stimulation. Each group was divided into 6h, 1d, 7d and 21d after thoracotomy separately, HRV frequency domain analysis was performed by HRV recording and analysis system in rats. Results After 6 hours of ligation, the frequency-domain analysis of the FNS group showed that the low-frequency components of the FNS group were significantly lower than those of the AMI and FNL groups (P <0.01), and the high-frequency components of the FNS group were significantly higher than those of the other intervention groups Frequency components and the decrease of low-frequency components (P <0.05). After 7 days, only high-frequency power was retained in the sham operation group, and the difference between the intervention groups disappeared. After 21 days, difference. There was no significant difference in HRV parameters between FNL group and AMI group at each time point (P> 0.05). Conclusion Electrical stimulation of cerebellar fastigial nucleus can improve HRV in AMI rats.
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