目的探讨第三代芳香化酶抑制剂(aromatase inhibitors,AIs)来曲唑对人子宫内膜癌裸鼠移植瘤生长的作用。方法2006年5月至6月于南京军区南京总医院、南京大学医学院临床学院,将人子宫内膜癌细胞株RL-952接种于裸鼠皮下,建立裸鼠的移植瘤动物模型,随机分成5组,分别给予包括来曲唑在内的药物干预。8周后计算移植瘤体积、抑瘤率及裸鼠体重情况,肿瘤组织标本进行HE染色病理检查,流式细胞术检测细胞周期及凋亡情况。结果实验组裸鼠肿瘤体积增长相对缓慢[来曲唑1组(2539.83±461.23)mm3、来曲唑2组(2330.02±496.84)mm3];对照组肿瘤体积增长明显[治疗后为(3787.94±697.54)mm3],差异有统计学意义(P<0.01);流式细胞术检测实验组肿瘤细胞凋亡率[来曲唑1、2组分别为(32.90±5.76)%,(35.80±5.12)%]明显高于对照组[(16.97±4.80)%](P<0.05)。结论来曲唑抗子宫内膜癌作用与醋酸甲地孕酮(megestrol ace-tate,MA)相似。 Objective To investigate the effect of the third generation aromatase inhibitors (AIs) letrozole on the growth of human endometrial carcinoma xenografts in nude mice. Methods The human endometrial carcinoma cell line RL-952 was inoculated subcutaneously in nude mice from April 2006 to June 2006 in the Nanjing General Hospital of Nanjing Military Command and the School of Medicine, Nanjing University School of Medicine. The nude mice were randomly divided into three groups 5 groups were given drug intervention including letrozole. After 8 weeks, the volume of tumor xenograft, tumor inhibition rate and body weight of nude mice were calculated. The tumor tissue samples were examined by HE staining and the cell cycle and apoptosis were detected by flow cytometry. Results The growth of tumor volume in nude mice was relatively slow in the experimental group (2539.83 ± 461.23 mm 3 for letrozole and 2330.02 ± 496.84 mm 3 for letrozole), and the volume of tumor in the control group increased significantly (3787.94 ± 697.54 ) mm3], the difference was statistically significant (P <0.01). The apoptosis rate of tumor cells in experimental group was detected by flow cytometry [(32.90 ± 5.76)%, (35.80 ± 5.12)% ] Was significantly higher than that of the control group [(16.97 ± 4.80)%] (P <0.05). Conclusion Letrozole has similar anti-endometrial cancer effect to megestrol ace-tate (MA).