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研究了解新疆维吾尔族冠心病患者血管紧张素转换酶(ACE)基因、内皮型一氧化氮合酶(eNOS)基因、凝血因子VII(FVII)基因、细胞黏附分子-1(ICAM-1)基因等的多态性变化。入选已确诊的维吾尔族冠心病患者124例和维吾尔族健康志愿者50例,采用聚合酶链式反应-限制性片段多态性(PCR-RFLP)方法,分别检测及比较维吾尔族冠心病患者及健康志愿者4种基因型及其等位基因频率。结果显示,冠心病组与健康对照组相比,ACE基因、FVII基因、ICAM-1基因在基因型及等位基因频率方面均无显著性差异(P>0.05);冠心病组在eNOS基因型和等位基因频率分布两方面与健康对照组比较,均有显著性差异(P<0.05)。结论为ACE基因、FVII基因、ICAM-1基因多态性与新疆维吾尔族冠心病患者的关系不明显,而eNOS基因多态性与维吾尔族冠心病患者有相关性。
To investigate the relationship among angiotensin converting enzyme (ACE) gene, endothelial nitric oxide synthase (eNOS) gene, factor VII (FVII) gene and cell adhesion molecule-1 (ICAM-1) gene in patients with Uygur in Xinjiang Uygur Polymorphism changes. 124 cases of diagnosed Uighur coronary heart disease and 50 healthy Uygur volunteers were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect and compare Uygur patients with coronary heart disease Four genotypes of healthy volunteers and their allele frequency. The results showed that ACE gene, FVII gene and ICAM-1 gene had no significant difference in genotype and allele frequencies between coronary heart disease group and healthy control group (P> 0.05). In coronary heart disease group, eNOS genotype And allele frequency distribution both compared with the healthy control group, there was a significant difference (P <0.05). Conclusion There is no significant relationship between ACE gene, FVII gene and ICAM-1 gene polymorphism and Uygur patients with coronary heart disease in Xinjiang Uygur nationality. However, eNOS gene polymorphism is associated with Uygur patients with coronary heart disease.