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目的探讨高血压病程及血脂与冠状动脉造影病变程度的关系。方法502例住院患者作为研究对象,所有病例均经选择性冠状动脉造影分组,按照有无冠状动脉狭窄及其程度分为:无病变及狭窄性病变、斑块浸润性病变、单支病变、双支病变、三支病变及弥漫病变五组;所有患者入院后测量血压,并对每一个患者进行高血压和糖尿病病史的调查,测定血脂水平;经桡动脉或股动脉途径进行选择性冠状动脉造影。结果随着冠状动脉造影病变程度分级的加重,高血压组患者数逐渐增加,卡方检验示P<0.01,有显著性统计学意义。在冠状动脉造影病变程度的分级各组中,随着病变程度的加重高血压患者的比例逐渐增多,说明高血压病是冠状动脉病变严重程度的相关因素。高血压病患者的发病病程,随着冠状动脉造影病变程度分级的加重,高血压组患者病程数值逐渐增加,One-WayANOVA过程检验示P<0.01,有显著性统计学意义。随着冠状动脉狭窄程度的加重,血浆总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B、三酰甘油、脂蛋白(a)水平呈逐渐增高趋势;载脂蛋白A1(ApoAl)、高密度脂蛋白胆固醇有下降的趋势;年龄愈大,冠脉病变的严重程度愈重;体质量、三酰甘油水平在冠心病各组中无明显差别。结论高血压病是冠状动脉病变严重程度的相关因素,高血压病患者病程愈长冠状动脉造影病变程度及范围愈重。
Objective To investigate the relationship between the course of hypertension and the severity of coronary angiography. Methods A total of 502 inpatients were selected as study subjects. All cases were divided by selective coronary angiography. According to the presence or absence of coronary artery stenosis and its extent, the patients were divided into three groups: non-lesion and stenosis, plaque-infiltrative lesion, Branch disease, three lesions and diffuse lesions in five groups; all patients measured blood pressure after admission, and for each patient with hypertension and diabetes history survey, determination of lipid levels; radial artery or femoral artery by selective coronary angiography . Results With the severity of coronary angiography grading increased, the number of patients with hypertension increased gradually, chi-square test showed P <0.01, with significant statistical significance. In the grading of coronary angiography grade, the proportion of hypertensive patients gradually increased with the severity of the disease, indicating that hypertension is the related factor of the severity of coronary artery disease. Hypertension patients with the onset of disease, with the severity of coronary angiography grade grading, patients with hypertension increased course of disease values, One-WayANOVA process showed P <0.01, statistically significant. With the severity of coronary artery stenosis, plasma total cholesterol, low density lipoprotein cholesterol, apolipoprotein B, triglyceride and lipoprotein (a) levels showed a trend of increasing trend; apolipoprotein A1 (ApoAl), high density lipids Protein cholesterol have a downward trend; the older, the more serious the severity of coronary lesions; body weight, triglyceride levels in coronary heart disease in each group no significant difference. Conclusion Hypertension is the related factor of the severity of coronary artery disease. The longer the course of Hypertension patients, the more severity and extent of coronary angiography.