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在近20年上市的农药中有将近70%的物质至少含有一个杂环结构。目前,销售额位列前茅的一些商品化的农药产品,如广谱杀菌剂嘧菌酯和新烟碱类杀虫剂吡虫啉,其主要成分都属于杂环化合物这一庞大群体。在农药先导优化中,杂环的巨大作用主要体现在以下几点:首先,农药中的杂环结构通常对于化合物的合成有着很大的影响(使化合物更易合成),同时也对其物化性质起到关键的作用,
Nearly 70% of pesticides marketed in the past 20 years contain at least one heterocyclic structure. Currently, some of the top commercialized pesticide products, such as the broad-spectrum bactericide azoxystrobin and the neonicotinoid insecticide imidacloprid, are among the top-selling ingredients in the large group of heterocyclic compounds. In the pesticide pilot optimization, the great role of heterocyclic ring mainly in the following points: First, the heterocyclic structure of pesticides usually have a great impact on the synthesis of compounds (compounds more easily synthesized), but also its physical and chemical properties To the crucial role,