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香草醛经甲基化、硝化、氧化、酯化、还原、环合、氯化及氨化制得盐酸特拉唑嗪等喹唑啉类药物的中间体4-氨基-2-氯-6,7-二甲氧基喹唑啉,并考察了硝化、氧化过程中反应温度和投料比等因素对反应的影响,确立了最佳工艺条件,总收率约37%。
Vanillin by methylation, nitration, oxidation, esterification, reduction, cyclization, chlorination and ammoniation obtained terazosin hydrochloride and other quinazoline drugs intermediates 4-amino-2-chloro-6, 7-dimethoxyquinazoline. The effects of reaction temperature and feeding ratio on the reaction were investigated. The optimum process conditions were established and the total yield was about 37%.