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目的研究分析卵巢浆黏液性癌的免疫表型和病理特征,并对患者预后特点进行分析。方法 2 0 0 4年1 0月-2 0 1 2年1 0月收住焦煤集团中央医院的卵巢浆黏液性癌患者1 9例,依据国际妇产科联盟(International Federation of Gynecology and O bstetrics,FIGO)对患者进行病理分期,免疫组化法检测病灶组织中ARID1 A、ER、PR以及P53表达,分析患者预后。结果与同期2 6例卵巢胃肠型黏液性癌患者进行比较。卵巢浆黏液性癌患者病理分期多为Ⅱ~Ⅳ期差异有统计学意义(P<0.0 5),患者3年生存率低于卵巢胃肠型黏液性癌差异有统计学意义(P<0.0 5)。卵巢浆黏液性癌ARID1 A、ER及PR表达阳性率高于卵巢胃肠型黏液性癌差异有统计学意义(P<0.0 5),但两者P53表达阳性率差异无统计学意义(P>0.0 5)。结论卵巢浆黏液性癌病理特征复杂,患者预后较差。基因表达水平可能与卵巢浆黏液性癌的恶性程度有关。
Objective To study the immunophenotypic and pathological features of ovarian mucinous carcinoma and to analyze the prognosis of the patients. Methods A total of 19 ovarian mucinous carcinoma patients admitted to Coking Central Hospital from January 2004 to October 2012 were selected according to the International Federation of Gynecology and O bstetrics FIGO). The expression of ARID1 A, ER, PR and P53 were detected by immunohistochemistry and the prognosis was analyzed. The results were compared with 26 cases of ovarian gastrointestinal mucinous carcinoma in the same period. The pathological stage of ovarian mucinous mucinous carcinoma was mostly stage Ⅱ ~ Ⅳ (P <0.0 5), and the 3-year survival rate of ovarian mucinous carcinoma was lower than that of ovarian mucosa (P <0.05) ). The positive rates of ARID1 A, ER and PR in ovarian mucinous mucinous carcinoma were significantly higher than those in ovarian mucosa (P <0.05), but there was no significant difference between the two groups (P> 0.0 5). Conclusion Ovarian mucinous carcinomas have complicated pathological features and poor prognosis. The gene expression level may be related to the malignant degree of ovarian mucinous carcinoma.