论文部分内容阅读
褪黑素(melatonin,MT)作为松果体分泌的一种激素,参与神经-内分泌-免疫网络的调控,从不同层次对免疫应答发挥上调作用.MT在免疫系统内结合位点的分布具有一定特征.各种外源性因素(光照周期改变、冷水束缚刺激、连续超声、免疫抑制剂、松果体切除、化学物等)及内源因素(年龄老化)对大、小鼠细胞免疫和体液免疫功能均有一定的损害作用,而MT能拮抗这此损害效应,不同程度地恢复机体的免疫功能.对MT免疫应答上调作用机理的深入探讨,将有助于对免疫过程的认识和对其临床应用价值的了解.
As a hormone secreted by pineal gland, melatonin (MT) participates in the regulation of neuroendocrine-immune network and plays an upregulation role in immune response from different levels.MT has a certain distribution of binding sites in the immune system Characteristics of various exogenous factors (light cycle changes, cold water binding stimulation, continuous ultrasound, immunosuppressive agents, pineal resection, chemicals, etc.) and endogenous factors Immune function have some damage, and MT can antagonize this damaging effect, to varying degrees, to restore the body’s immune function.To investigate the mechanism of up-regulation of the immune response in MT, will help to understand the immune process and its Clinical application of the value of understanding.