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目的 探讨p5 3、C erbB 2在人乳腺癌组织中的表达及预后评价中的作用。方法 免疫组化检测 5 9例人乳腺癌石蜡切片 p5 3、C erbB 2的表达 ,并与肿瘤大小、淋巴结转移和肿瘤复发率对比分析。结果 p5 3阳性表达与腋淋巴结转移、肿瘤大小(P <0 .0 5 )和肿瘤复发呈正相关 (P <0 .0 1) ;C erbB 2阳性表达与腋淋巴结转移 (P <0 .0 1)和肿瘤复发呈正相关 (P <0 .0 5 ) ;两者同时阳性表达亦与肿瘤复发呈显著正相关 (P <0 .0 1)。结论 p5 3、C erbB 2表达与人乳腺癌预后有一定相关性 ,两者同时阳性表达可能提示预后更差
Objective To investigate the expression of p5 3 and C erbB 2 in human breast cancer and their role in prognosis evaluation. Methods Immunohistochemistry was used to detect the expression of p53 and C erbB 2 in 59 breast cancer samples, which were compared with the tumor size, lymph node metastasis and tumor recurrence rate. Results The positive expression of p53 was positively correlated with axillary lymph node metastasis, tumor size (P <0.05) and tumor recurrence (P <0.01). The positive expression of C erbB 2 was correlated with axillary lymph node metastasis (P <0.01) ) Was positively correlated with tumor recurrence (P <0.05). The positive expression of both of them was also positively correlated with tumor recurrence (P <0.01). Conclusion The expression of p5 3 and C erbB 2 have some correlation with the prognosis of human breast cancer. The simultaneous positive expression of both may be a sign of worse prognosis