目的 :探讨冲击波暴露后 6h ,12h ,青年、老年豚鼠耳蜗血管纹微血管通透性和听阈的变化。方法 :采用胶体镧作为电子示踪剂透射电镜下观察。结果 :冲击波暴露后 6h、12h两组豚鼠听阈均较暴露前明显下降 (P <0 .0 5 ) ,微血管内皮细胞之间的紧密连接遭到破坏 ,老年组更为明显。结论 :暴露后早期听阈阈值的升高 ,可能与血管纹微血管通透性改变密切相关。 Objective: To investigate the changes of capillary vascular permeability and auditory threshold in guinea pig cochleas at 6h, 12h after shock wave exposure. Methods: The colloidal lanthanum was used as electron tracer for TEM observation. Results: The hearing thresholds of guinea pigs in both groups were significantly decreased 6h and 12h after shock wave exposure (P <0.05), and the tight junctions between microvascular endothelial cells were destroyed, especially in the aged group. Conclusion: The increased threshold threshold after exposure may be closely related to the changes of vascular microvascular permeability.