维持性血液透析患者(MHD)的中长期并发症与中大分子清除率低下相关,这些中大分子的长期积累给MHD的长期生存提出了挑战[1],甲状旁腺素(PTH)和β2MG等中大物质在体内显著增高可造成患者心肌损害,周围性神经病变、皮肤瘙痒、骨痛等严重影响患者生活时间和质量的并发症,2011年肾脏血液透析登记报告我国透析患者2%死于心血管疾病。50%—70%的终末期患者有皮肤瘙痒症 The long-term and long-term complications of maintenance hemodialysis patients (MHD) are associated with a low clearance of macromolecules. The long-term accumulation of these macromolecules poses a challenge to the long-term survival of MHD [1], parathyroid hormone (PTH) and β2MG Such as medium and large substances in the body significantly increased can cause myocardial damage in patients with peripheral neuropathy, itchy skin, bone pain and other serious impact on patient life time and quality of complications, renal dialysis 2011 registration report 2% of patients died of dialysis in China Cardiovascular diseases. 50% -70% of patients with end-stage pruritus