论文部分内容阅读
目的研究氢化可的松、对氨基水杨酸、水杨酸偶氮磺胺吡啶三种灌肠剂治疗左半结肠溃疡性结肠炎（ＵＣ）的疗效和安全性。方法用随机双盲对照方法对６２例ＵＣ病人分组治疗，以安慰剂为对照，疗程４周，观察临床症状、结肠镜和组织学炎症及疾病活动指数（ＤＡＩ）的改善情况。结果三种灌肠剂和对照组治疗后症状改善率分别为７５％、６８．７％、６８．７％和２１．４％（Ｐ＜０．０５）；结肠镜下炎症改善率为７５％、６８．７％、６１．５％和７．１％（Ｐ＜０．０５）；组织学改善率为６２．８％、５０．０％、４３．２％和７．１％（Ｐ＜０．０５）；三个治疗组ＤＡＩ指数均有明显下降（Ｐ＜０．００１）。无严重副作用。结论三种灌肠剂均为有效、简便、安全的左半结肠ＵＣ的局部治疗药物。
Objective To study the efficacy and safety of three hydrocortisone, para-aminosalicylic acid and salicylazosulfapyridine in the treatment of left-colon ulcerative colitis (UC). Methods Sixty-two patients with UC were divided into two groups according to a randomized, double-blind comparison. The placebo was used as the control. The course of treatment was 4 weeks. The clinical symptoms, colonoscopy and histological inflammation and the improvement of disease activity index (DAI) were observed. Results The symptom improvement rates of the three enemas and the control group after treatment were 75%, 68.7%, 68.7% and 21.4%, respectively (P <0.05); the improvement rate of colon inflammation was 75% 68.7%, 61.5% and 7.1%, respectively (P <0.05). The histologic improvement rates were 62.8%, 50.0%, 43.2% and 7.1% .05). DAI index of three treatment groups decreased significantly (P <0.001). No serious side effects. Conclusion All three enemas are effective, simple and safe topical treatment of left colon UC.