磁性纳米粒子具有可以与所感兴趣的生物细胞相结合并增强其磁信号的特点。本研究利用医用脑磁仪中的高灵敏度磁检测系统,对基于纳米磁性粒子的肿瘤早期检测方法进行了探究。论文对4种可与肿瘤细胞结合的不同尺度磁性纳米粒子所产生的磁场进行了检测和仿真分析,并进行了初步的动物实验。结果显示,利用超导量子干涉仪(SQUID)构成的高精度磁检测系统可以对50 nm以上尺度的磁性粒子进行有效检测,该研究为开发基于SQUID和磁性纳米粒子的肿瘤细胞早期检测系统奠定了基础。 Magnetic nanoparticles have the characteristic of binding to biological cells of interest and enhancing their magnetic signals. In this study, the high sensitivity magnetic detection system in medical brain magnetism was used to investigate the early detection of tumor based on nano-magnetic particles. In this paper, the magnetic fields generated by four kinds of magnetic nanoparticles with different scales binding to tumor cells were detected and simulated, and preliminary animal experiments were carried out. The results show that magnetic detection system based on SQUID can effectively detect magnetic particles above 50 nm. This study laid the foundation for the development of an early detection system for tumor cells based on SQUID and magnetic nano-particles basis.