本文报告两例华支睾吸虫感染兔的肝组织透射电镜观察结果。肝细胞主要变化是胞浆内胆色素颗粒增多,粗面内浆网扩张,次级溶酶体增多。毛细胆管扩张,其内微绒毛变形、不规则、甚至消失。作者认为这些超微结构改变属于肝内郁胆,与华支睾吸虫胆道寄生引起胆道不完全性梗阻有关。因此,严重的华支睾吸虫感染对肝细胞有损伤作用。 This article reports the results of transmission electron microscopy of two liver tissues infected with Clonorchis sinensis. The main changes of liver cells are intracytoplasmic pigment particles increased, coarse mesh network expansion, increased secondary lysosomes. Capillary bile duct dilatation, its microvilli deformation, irregular, or even disappear. The authors believe that these ultrastructural changes belong to the liver gallbladder, and Clonorchis sinensis biliary parasites caused by incomplete biliary obstruction. Therefore, severe Clonorchis sinensis infection has damaging effects on hepatocytes.