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肾病在维持血糖稳态方面起到了非常重要的生理作用:肾病每天可过滤近200克葡萄糖,并且重吸收所有这些葡萄糖以保持热量。这一机制由肾近端小管第一段水平的可溶性葡萄糖转运蛋白的活性来调节。在正常个体中,SGLT2负责至少90%的葡萄糖吸收。其余10%由下游一类的SGLT1作用来重吸收,从而完成100%的葡萄糖重吸收。而在2型糖尿病时,这种重吸收过程增强。特异性抑制SGLT2可以预防重吸收。增加尿糖排出,降低血糖。目
Nephropathy plays a very important physiological role in maintaining blood glucose homeostasis: nephropathy can filter nearly 200 grams of glucose daily, and reabsorb all of the glucose to keep it warm. This mechanism is regulated by the activity of soluble glucose transporters at the first stage of the renal proximal tubule. In normal individuals, SGLT2 is responsible for at least 90% glucose uptake. The remaining 10% is reabsorbed by the downstream SGLT1 to complete 100% glucose reabsorption. In type 2 diabetes, this reabsorption process is enhanced. Specific inhibition of SGLT2 can prevent reabsorption. Increase urinary excretion, lower blood sugar. Head