宫颈癌结局预测

来源 :世界核心医学期刊文摘(妇产科学分册) | 被引量 : 0次 | 上传用户:liuqingq
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Background. To determine the impact of race and other factors on the management and outcomes of women treated for cervical cancer in a rural state. Methods. Following IRB approval, a retrospective review identified 434 eligible women treated for cervical cancer from 1994 to 2000. Collected data included: demographics, clinicopathologic data, primary and adjuvant therapy, recurrence, and survival. Statistical analyses were performed with the Chi-square test, Kaplan-Meier method, and Cox regression. Results. 304 (70%) of the women were white and 130 (30%) were non-white. Non-whites were more likely to present with advanced stage disease Stage IIB-IVB (25%vs 13%; P < 0.01). Whites were more likely to smoke, be married, be employed, and have private insurance. Non whites were more likely to have medical co-morbidities such as diabetes and hypertension. Although whites with early stage disease were more likely to undergo surgery as their primary therapy than non-whites (93%vs 84%; P < 0.01), survival was similar. Survival outcomes for advanced stage disease were similar between groups. Conclusions. Non-whites diagnosed with cervical cancer are more likely to present with advanced stage disease than whites; however, overall survival was similar between groups. Non-whites with early stage disease were more likely to receive primary radiation therapy than whites. The decision to use radiation therapy vs surgery does not appear to have a detrimental effect on overall survival, but may impact quality of life. Background. To determine the impact of race and other factors on the management and outcomes of women for cervical cancer in a rural state. Methods. Following IRB approval, a retrospective review identified 434 eligible women treated for cervical cancer from 1994 to 2000. Data included: demographics, clinicopathologic data, primary and adjuvant therapy, recurrence, and survival. Statistical analyzes were performed with the Chi-square test, Kaplan-Meier method, and Cox regression. Results. 304 (70%) of the women were white Non-whites were more likely to present with advanced stage disease Stage IIB-IVB (25% vs 13%; P <0.01). Whites were more likely to smoke, be married, be employed, and have private insurance. Non whites were more likely to have medical co-morbidities such as diabetes and hypertension. 93% vs 84% ; P <0.01) Survival outcomes for advanced stage disease were similar between groups. Conclusions. Non-whites diagnosed with cervical cancer are more likely to present with advanced stage disease than whites; however, overall survival was similar between groups. Non-whites with early stage disease were more likely to receive primary radiation therapy than whites. The decision to use radiation therapy vs surgery does not appear to have a detrimental effect on overall survival, but may impact quality of life.
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