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作者应用大鼠坏死性胰腺炎模型，探讨胰腺缺血在坏死性胰腺炎疾病的全过程中是否是持续损害因子。检测五组大鼠血浆内血栓素Ｂ２（ＴＸＢ２）、前列腺素Ｆ１α（ＰＧＦ１α）的浓度及血清内血管紧张素转化酶（ＡＣＥ）的活性。结果表明，实验组的ＴＸＢ２、ＰＧＦ１α与对照组皆有显著差异性（Ｐ＜０．０５）。ＡＣＥ，除６小时的活性低于对照组（两者无差异）外，其它实验组显著高于对照组（Ｐ＜０．０５）。由上推测，导致坏死性胰腺炎缺血的因素持续存在。因此，胰腺缺血是坏死性胰腺炎的持续损害因子，既是起始因子，又是恶化因子，且不可能出现再灌注损伤现象。
The authors apply rat model of necrotizing pancreatitis to investigate whether pancreatic ischemia is a persistent damage factor in the whole process of necrotizing pancreatitis. The concentrations of thromboxane B2 (TXB2), prostaglandin F1α (PGF1α) and the activity of serum angiotensin converting enzyme (ACE) in the five groups were detected. The results showed that TXB2 and PGF1α in the experimental group were significantly different from the control group (P <0.05). ACE, except 6 hours activity lower than the control group (no difference between the two), the other experimental group was significantly higher than the control group (P <0.05). By speculating, the factors that cause ischemia in necrotizing pancreatitis persist. Therefore, pancreatic ischaemia is a persistent damage factor of necrotizing pancreatitis, both as a starting factor, but also a deteriorating factor, and the phenomenon of reperfusion injury may not occur.