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目的观察5-氨基酮戊酸光动力(ALA-PDT)联合CO2激光治疗鲍温样丘疹病的临床疗效。方法将2010年1月~2012年12月期间前来我院皮肤科门诊就诊的30例鲍温样丘疹病患者按随机数字表分成观察组18例和对照组12例。对照组采用CO2激光治疗,观察组采用ALA光动力联合CO2激光进行治疗,连续治疗4次,每次治疗间隔时间1周。比较两组的治疗有效率、复发率和不良反应。结果完成治疗1月后治疗组有效率为94.44%;对照组有效率我58.33%;组间比较其差异有统计学意义(χ2=5.868,P<0.05)。6个月后复查治疗组复发率为8.33%;对照组复发率为50%。组间比较其差异有统计学意义(χ2=4.018,P<0.05)。结论 CO2激光联合ALA光动力治疗鲍温样丘疹病是一种疗效确切,复发率较低的新型治疗方法,具有临床推广的价值。
Objective To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser treatment of Bowenoid papulosis. Methods From January 2010 to December 2012, 30 cases of Bowenoid papulosis who came to dermatology clinic in our hospital were divided into observation group (n = 18) and control group (n = 12) according to random number table. The control group was treated with CO2 laser. The observation group was treated with ALA photodynamic therapy combined with CO2 laser. The treatment group was treated 4 times in succession, and each treatment interval was 1 week. Compare the two groups of treatment efficiency, recurrence rate and adverse reactions. Results After treatment for one month, the effective rate was 94.44% in the treatment group and 58.33% in the control group. There was significant difference between the two groups (χ2 = 5.868, P <0.05). The recurrence rate of the treatment group was 8.33% after 6 months and that of the control group was 50%. The difference between the two groups was statistically significant (χ2 = 4.018, P <0.05). Conclusion CO2 laser combined with ALA photodynamic therapy for Bowenoid papulosis is a new treatment method with definite curative effect and low relapse rate, which has the value of clinical popularization.