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目的:探讨洗胃后配合间歇胃肠减压治疗新生儿顽固性呕吐的临床疗效及安全性。方法:将2009年1月～2012年6月我院儿科收治124例顽固性呕吐的新生患儿随机分为两组,每组各62例。所有患儿均给予病因治疗、体位治疗、维持水电解质及酸碱平衡等常规综合治疗。在此基础上,对照组给予温盐水洗胃治疗,治疗组给予洗胃后配合间歇胃肠减压治疗。观察和比较两组患儿的临床疗效、体重和胃肠功能变化及不良反应。结果:治疗后,治疗组患儿总有效率为90.3%,显著高于对照组总有效率为75.8%(P<0.05);与对照组比较,治疗组患儿顽固性呕吐症状的缓解时间、胃肠功能完全恢复时间明显缩短,体重减轻程度较轻(P<0.05);两组患儿均未见坏死性肠炎、新生儿窒息等严重不良反应。结论:洗胃后配合间歇胃肠减压可提高临床疗效及促进胃肠功能恢复,简单安全,可作为新生儿顽固性呕吐理想的治疗方法。
Objective: To investigate the clinical efficacy and safety of gastric lavage combined with intermittent gastrointestinal decompression in neonatal refractory emesis. Methods: From January 2009 to June 2012, 124 infants with refractory vomiting admitted to our pediatric department were randomly divided into two groups, 62 in each. All children were given etiological treatment, physical therapy, to maintain water and electrolyte and acid-base balance and other conventional comprehensive treatment. On this basis, the control group was given warm salt water lavage treatment, the treatment group given gastric lavage followed by intermittent gastrointestinal decompression. The clinical efficacy, body weight, gastrointestinal function and adverse reactions in both groups were observed and compared. Results: After treatment, the total effective rate was 90.3% in the treatment group and significantly higher than that in the control group (75.8%, P <0.05). Compared with the control group, the remission time of refractory vomiting, The complete recovery time of gastrointestinal function was significantly shortened, and the degree of weight loss was lighter (P <0.05). No serious adverse reactions such as necrotic enteritis and neonatal asphyxia were observed in both groups. Conclusion: After gastric lavage with intermittent gastrointestinal decompression can improve clinical efficacy and promote gastrointestinal function recovery, simple and safe, can be used as an ideal neonatal treatment of intractable vomiting.