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目的研究丁苯酞对血管性痴呆(VD)患者认知功能的影响、生活能力的改善及安全性。方法选择临床明确诊断为VD的患者62例,随机分为对照组和治疗组,对照组予以常规口服阿司匹林、吡拉西坦治疗,治疗组在以上治疗基础上加用丁苯酞长期口服,以60 d为一个评定周期,两组患者在治疗前及治疗60 d分别对其进行简易智能状态量表(MMSE)和日常生活能力表(ADL)评分,并进行比较,同时评价丁苯肽软胶囊的药物不良反应。结果两组治疗后的MMSE及ADL评分较治疗前均有显著提高(P<0.01),与对照组相比,治疗组治疗后MMSE及ADL评分较对照组改善更为明显,两组治疗后评分比较差异具有统计学意义(P<0.05)。结论丁苯肽联合吡拉西坦治疗血管性痴呆临床有效,能显著改善VD患者的认知功能,且不良反应少。
Objective To investigate the effect of butylphthalide on cognitive function in patients with vascular dementia (VD), and to improve and improve the safety of life. Methods Sixty-two patients with definite clinical diagnosis of VD were randomly divided into control group and treatment group. The control group was given routine oral aspirin and piracetam. The treatment group was treated with butylphthalide long-term oral 60 d for one evaluation cycle, two groups of patients before treatment and treatment of 60 d were assessed by the Mini-Intelligent State Scale (MMSE) and daily living ability (ADL) score, and compared, and evaluation of butanlin capsule Adverse drug reactions. Results The scores of MMSE and ADL after treatment in both groups were significantly higher than those before treatment (P <0.01). Compared with the control group, the scores of MMSE and ADL in the treatment group improved more obviously than those in the control group. After treatment, The difference was statistically significant (P <0.05). Conclusion DBT combined with piracetam is effective in treating vascular dementia and can significantly improve the cognitive function of VD patients with less adverse reactions.