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目的:观察白细胞介素11联合地塞米松治疗急性放射性口腔炎的疗效。方法:将92例放疗过程中出现了三级放射性口腔炎的鼻咽癌患者随机分为试验组和对照组各46例,试验组予以白细胞介素11溶液联合地塞米松溶液交替含漱,对照组则用地塞米松溶液含漱及抗生素静滴,每日对口腔溃疡及疼痛的程度进行评估。结果:试验组的溃疡愈合有效率为93.4%,疼痛减轻的有效率为95.7%,而对照组则为81.4%和84.8%,两组数据有统计学差异。结论:白细胞介素11联合地塞米松含漱治疗放射性口腔炎疗效较好,可减少抗生素的使用。
Objective: To observe the efficacy of interleukin-11 combined with dexamethasone in the treatment of acute radiation stomatitis. Methods: A total of 92 patients with stage Ⅲ radiation stomatitis who had radiotherapy stomatitis were randomly divided into experimental group and control group, with 46 cases in each group. Interleukin-11 and dexamethasone solution were alternately rinsed in the experimental group, while the control group Group dexamethasone solution rinsed with antibiotics, daily oral ulcers and pain assessment. Results: The effective rate of ulcer healing was 93.4% and the pain relief rate was 95.7% in the test group compared with 81.4% and 84.8% in the control group. There was significant difference between the two groups. Conclusion: Interleukin 11 combined with dexamethasone rinse for radiation stomatitis is effective and can reduce the use of antibiotics.