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目的 探讨老年睡眠呼吸暂停低通气综合征(SAHS)患者心率变异性的特点及持续气道正压通气(nCPAP)治疗对其的影响。 方法 老年轻、中、重度、非老年重度 SAHS患者及健康老年对照者各20例进行多导睡眠图及动态心电图检测,计算夜间睡眠期间连续RR间期平均值和标准差及24 h低频(LF)、高频(HF)和LF/HF值,定量分析心率变异性。其中 21 例老年中、重度 SAHS患者行nCPAP治疗 3 个月后予以复查。 结果 老年中度、老年重度、非老年重度 SAHS患者 RR间期平均值和RR间期标准差〔(764 .3±131 .0)ms、(709 .4±101. 8)ms、(759. 5±80 .0)ms和(37. 5±12 .2)ms、(31. 5±9 .6)ms、(41 .4±10 .6)ms〕与对照者〔(847. 9±113 .8)ms和(45. 7±16 .2)ms〕比较,均明显降低(P<0 .05),老年重度也较非老年重度 SAHS患者明显降低(P<0 .05)。老年中度、老年重度和非老年重度SAHS患者的LF、HF和 LF/HF值分别为〔(290. 5±78. 5)ms2、(420 .3±102 .8)ms2、(316. 9±101. 3)ms2,(156 .6±64 .5)ms2、(300 .5±56. 1)ms2、(203 .3±141 .1)ms2和 2. 1±0 7 、2 2±0 9、2 9±2 2〕,与健康老年对照组〔(197 .7±154. 9)ms2、(86 .3±73 .4) ms2和2. 9±1. 8〕比较,差异有统计学意义(均为 P< 0. 05);老年重度与非老年重度组
Objective To investigate the characteristics of heart rate variability in elderly patients with sleep apnea-hypopnea syndrome (SAHS) and the effect of continuous positive airway pressure (nCPAP) therapy on it. Methods 20 patients with severe, moderate, severe, non-elderly severe SAHS and healthy elderly controls were included in this study. Polysomnography and Holter monitoring were performed in 20 patients. The mean and standard deviation of RR intervals and the frequency of LF ), High frequency (HF), and LF / HF values for quantitative analysis of heart rate variability. Among 21 elderly patients with moderate and severe SAHS, they were reviewed after 3 months of nCPAP treatment. Results The mean RR interval and standard deviation of RR interval were (764.3 ± 131.0) ms, (709.4 ± 101.8) ms, (759) in elderly patients with moderate to severe senile severe non-elderly severe SAHS. 5 ± 80 .0) ms and (37.5 ± 12.2) ms, (31.5 ± 9.6) ms, (41.4 ± 10.6) ms] 113.8) ms and (45.7 ± 16.2) ms] were significantly lower (P <0 .05), and senile severe than non-elderly patients with severe SAHS was significantly lower (P <0 .05). The values of LF, HF and LF / HF in senile, elderly and non-elderly patients with severe SAHS were (290.5 ± 78.5) ms2, (420.3 ± 102.8) ms2 and ± 101. 3) ms2, (156.6 ± 64.5) ms2, (300.5 ± 56.1) ms2, (203.3 ± 141.1) ms2 and 2.1 ± 0.7, 2 2 ± 0 9,2 9 ± 2 2〕, compared with healthy elderly control group 〔(197.7 ± 154.9) ms2, (86.3 ± 73.4) ms2 and 2.9 ± 1.8〕, the difference was Statistical significance (all P <0.05); severe elderly and non-elderly severe group