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人工构建4只成年Beagle犬下颌后牙区牙周缺损模型,分别随机采用:胶原-羟基磷灰石人工骨/胶原膜、胶原-羟基磷灰石人工骨、空白对照治疗,每组8颗牙,12周后处死动物,进行组织学观察并测量新生组织高度。结果:与单纯植入胶原-羟基磷灰石人工骨组相比,胶原-羟基磷灰石人工骨/胶原膜组获得了更多的新附着,表现为有较多的新生牙槽骨、新生牙周膜和新生牙骨质样组织生长,2组之间新生组织差异有显著性(P<0.05)。结论:胶原-羟基磷灰石人工骨与胶原膜联合运用修复牙周牙槽骨缺损引导牙周组织
The model of periodontal defect in the posterior teeth of 4 adult Beagle dogs was constructed by artificial means: collagen-hydroxyapatite artificial bone / collagen membrane, collagen-hydroxyapatite artificial bone, blank control group, 8 teeth in each group After 12 weeks, the animals were sacrificed for histological observation and measurement of neonate tissue height. RESULTS: Compared with the artificial bone tissue implanted with collagen-hydroxyapatite alone, more new attachment was found in the collagen-hydroxyapatite artificial bone / collagen membrane group with more new alveolar bone and newborn The growth of periodontal ligament and nascent cementum tissue were significant (P <0.05). Conclusion: Collagen-hydroxyapatite artificial bone combined with collagen membrane can repair periodontal alveolar bone defects and guide periodontal tissue