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测定36例2型糖尿病患者和30例正常人的血清CRP水平,并与糖尿病相关代谢指标(FBG、BMI、WHR、HbA1c、SBP、DBP)比较分析;结果:2型糖尿病组患者的血清CRP浓度显著高于正常对照组(P<0.01);2型糖尿病患者血清CRP水平与病程、空腹血糖、BMI及WHR呈正相关;糖尿病组CSII治疗2周后,血糖明显下降,CRP水平也明显降低(P<0.01);结论对于存在严重胰岛素抵抗和分泌不足的血糖明显增高的2型糖尿病患者,短期使用CSII强化胰岛素治疗,快速有效地控制血糖,也使CRP水平明显下降,提示胰岛素本身的抗炎症作用。
Serum CRP levels were measured in 36 patients with type 2 diabetes mellitus and 30 normal subjects and compared with those related to diabetes mellitus (FBG, BMI, WHR, HbA1c, SBP and DBP). Results: Serum CRP levels in patients with type 2 diabetes mellitus (P <0.01). Serum CRP level was positively correlated with duration of disease, fasting blood glucose, BMI and WHR in type 2 diabetic patients. After 2 weeks of treatment, the blood glucose level and the CRP level in diabetic group were significantly decreased (P <0.01) .Conclusion Short-term intensive insulin treatment with CSII and rapid and effective control of blood glucose in type 2 diabetic patients with severe insulin resistance and hypogonadal hyperglycemia also markedly decreased the level of CRP, suggesting the antiinflammatory effect of insulin itself .