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目的:探讨不同剂量阿呋唑嗪在输尿管下段结石治疗中的有效性和安全性。方法:随机将83例输尿管下段结石患者分为4组.A组为对照组.B组每天加用2.5 mg阿呋唑嗪,C组每天加用5 mg阿呋唑嗪,D组每天加用7.5 mg阿呋唑嗪,观察对比4组患者结石排出率、排石时间、肾绞痛发生率、哌替啶使用剂量及体位性低血压等不良反应。结果:加用阿呋唑嗪的患者排石率提高.肾绞痛发生率下降,差异有统计学意义(P<0.05);B组的排石率和肾绞痛发生率与C组和D组比较.差异有统计学意义(P<0.05);C组和D组比较,差异无统计学意义。加用阿呋唑嗪的患者排石时间缩短.哌替啶使用剂量减少.差异有统计学意义(P.<0.01);B组的排石时间和哌替啶使用剂量分别与C组和D组比较.差异有统计学意义(P<0.05);C组的排石时间和哌替啶使用剂量和D组比较,差异无统计学意义。结论:阿呋唑嗪可以促进输尿管下段结石的排出.每天使用5 mg或7.5 mg治疗输尿管下段结石安全、高效。
Objective: To investigate the effectiveness and safety of different doses of alfaczine in the treatment of lower ureteral calculi. Methods: A total of 83 patients with lower ureteral calculi were randomly divided into 4 groups: group A was control group, group B was given 2.5 mg of alfuzosin daily, group C was given 5 mg of alfuzosin daily, and group D was added daily 7.5 mg of alfuzosin were observed and compared four groups of patients with stone discharge rate, stone row time, the incidence of renal colic, dosage of pethidine and orthostatic hypotension and other adverse reactions. Results: The rate of discharged stone was increased in the patients treated with alfuzosin and the incidence of renal colic decreased with a statistically significant difference (P <0.05). The rate of discharged stone and the incidence of renal colic in group B were significantly lower than those in group C and D The difference was statistically significant (P <0.05); there was no significant difference between C group and D group. Patients in the group treated with albuterol were shorter than those in the group treated with alfuzosin, and the dose of pethidine was decreased with a statistically significant difference (P <0.01) (P <0.05). There was no significant difference between group C and group D (P> 0.05). Conclusion: Alfuzosin can promote the discharge of lower ureteral stones.Using 5 mg or 7.5 mg daily for the treatment of lower ureteral stones is safe and effective.