论文部分内容阅读
目的研究妊娠期补充维生素E对母鼠及胎鼠脑组织受手机辐射影响的保护作用。方法 40只受孕大鼠随机分为5组,自妊娠第1天起,维生素E低、中、高剂量组分别按5 mg/kg、15 mg/kg、30 mg/kg的剂量补充,阴性对照组和阳性对照组灌服脱维生素E的花生油,同时给予1 h/次、3次/d的手机辐射,连续辐射21 d,分娩后测定母鼠及胎鼠脑组织总抗氧化能力(T-AOC)和ATP酶(Na+-K+-ATP酶和Ca+-Mg+-ATP酶)的活力变化。结果阳性对照组T-AOC、Na+-K+-ATP酶、Ca+-Mg+-ATP酶活性均较阴性对照组下降(P<0.05)。与阳性对照组比较,维生素E各剂量组T-AOC含量升高,其中,母鼠维生素E中、高剂量组较阳性对照组升高,胎鼠维生素E低、中、高剂量组均高于阳性对照组(P<0.05)。母鼠维生素E各剂量组Na+-K+-ATP酶和Ca+-Mg+-ATP酶活力均高于阳性对照组,胎鼠维生素E中、高剂量组ATP酶活力较阳性对照组升高(P<0.05)。结论维生素E对受手机辐射影响的母鼠及胎鼠的抗氧化能力和能量代谢有一定的保护作用。
Objective To study the protective effects of vitamin E supplementation during pregnancy on the radiation of mobile phone in the brains of maternal and fetal rats. Methods Forty pregnant rats were randomly divided into five groups. From the first day of pregnancy, the low, medium and high doses of vitamin E were supplemented with 5 mg / kg, 15 mg / kg and 30 mg / kg, respectively. The negative control Group and the positive control group were fed with vitamin E-free peanut oil and given cell phone radiation for 1 h / time and 3 times / d for 21 days. The total antioxidant capacity of brain tissue of maternal and fetal rats was measured after delivery (T- AOC) and ATPases (Na + -K + -ATPase and Ca + -Mg + -ATPase). Results The positive control group T-AOC, Na + -K + -ATPase, Ca + -Mg + -ATP enzyme activity than the negative control group decreased (P <0.05). Compared with the positive control group, the content of T-AOC in each dose group of vitamin E increased, in which, the vitamin E and the high dose group of the maternal mouse increased compared with the positive control group, the vitamin E, Positive control group (P <0.05). The activities of Na + -K + -ATPase and Ca + -Mg + -ATPase in the vitamin E group were higher than those in the positive control group, and the ATPase activity in the medium and high dose groups of vitamin E was higher than that of the positive control group (P <0.05 ). Conclusion Vitamin E has some protective effects on the antioxidation and energy metabolism of the female and fetus affected by cell phone radiation.