目的:改进复方珊瑚姜溶液尿素咪康唑软膏复合制剂中水杨酸的含量测定方法。方法:采用十八烷基硅烷键合硅胶为填充剂的色谱柱,以甲醇-0.4%磷酸溶液(60∶40)为流动相,流速1.0 m L/min,检测波长为305 nm,柱温25℃。结果:水杨酸在(0.0619 g~0.0746 g)范围内线性关系良好(R=1),方法回收率为101.12%(RSD=1.51%)。结论:该方法简便、快速、准确,可用于该制剂中水杨酸的定量测定。 OBJECTIVE: To improve the method for the determination of salicylic acid in compound micellar ointment compound coral ginger solution. Methods: The column was octadecylsilane bonded silica gel and the mobile phase was methanol - 0.4% phosphoric acid solution (60:40) at a flow rate of 1.0 mL / min. The detection wavelength was 305 nm and the column temperature was 25 ℃. Results: Salicylic acid had a good linear relationship (R = 1) in the range of 0.0619 g ~ 0.0746 g. The recovery rate was 101.12% (RSD = 1.51%). Conclusion: The method is simple, rapid and accurate and can be used for the quantitative determination of salicylic acid in this preparation.