有效保护内皮细胞是预防和治疗缺血再灌注损伤的关键 ,不同的预适应方式 ,如 :缺血 (缺氧 )、热休克及药物等 ,通过腺苷、ATP敏感性K+ 离子通道、热休克蛋白等机制介导了预适应对内皮细胞的保护作用 ,其中 ,药物预适应提供了良好的临床应用前景 Effective protection of endothelial cells is the key to the prevention and treatment of ischemia-reperfusion injury. Different preconditioning methods such as ischemia (hypoxia), heat shock and drugs, through adenosine, ATP-sensitive K + channels, heat shock Protein and other mechanisms mediate the protective effect of preconditioning on endothelial cells, of which, drug preconditioning provides a good clinical application prospects