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目的探讨血尿酸水平、颈动脉斑块与冠心病之间的关系。方法收集2006年1月2009年12月拟诊为冠心病的住院患者280例,冠状动脉造影检查冠状动脉狭窄程度>50%的194例为冠心病组,冠状动脉无狭窄或狭窄程度<50%的86例为对照组;冠心病组又分为单支、双支、多支病变亚组。分别测定冠心病组与对照组颈总动脉与颈动脉分叉处内膜中层厚度(IMT)、等级评分、Crouse积分、血尿酸浓度。结果与对照组相比,冠心病组颈总动脉与颈动脉分叉处IMT、等级评分、Crouse积分、血尿酸浓度均高于对照组,差异有统计学意义。在冠心病组,随病变分支的增多,颈动脉超声检查指标与血尿酸随之升高(P<0.05或0.01)。结论颈动脉IMT、等级评分、Crouse积分、血尿酸浓度与冠心病相关,是冠心病的独立危险因素。
Objective To investigate the relationship between serum uric acid level, carotid artery plaque and coronary heart disease. Methods A total of 280 inpatients suspected of coronary heart disease from January 2006 to December 2009 were enrolled in the study. Coronary artery angiography was performed in 194 patients with coronary stenosis> 50% for coronary heart disease. The degree of coronary artery stenosis or stenosis was <50% Of 86 patients as control group; coronary heart disease group is divided into single, double, multi-vessel disease subgroups. The intima-media thickness (IMT), grade score, Crouse score and serum uric acid concentration were measured in the bifurcation of common carotid artery and carotid artery in coronary heart disease group and control group respectively. Results Compared with the control group, IMT, grade score, Crouse score and serum uric acid concentration in the common carotid artery and carotid artery bifurcation in CHD group were significantly higher than those in control group, with statistical significance. In coronary heart disease group, the index of carotid artery ultrasonography and serum uric acid increased with the increase of lesion branches (P <0.05 or 0.01). Conclusion Carotid artery IMT, grade score, Crouse score, serum uric acid concentration and coronary heart disease are independent risk factors for coronary heart disease.