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目的:探讨C-crb B-2在生殖器尖锐湿疣(CA)中的表达,以及对CA近期预后的影响。方法:用免疫组化SP法检验39例CA病变中C-erb B-2的表达,并对CA的治疗情况进行随访。结果:39例CA中,7例(17.95％)C-erb B-2产物表达阳性,32例(82.05％)表达阴性。36例病人随访6-14月,均临床治愈,C-erb B-2产物表达阳性与表达阴性病人间的复发次数无显著性差异(P>0.05)。结论:CA中有C基因的激活和扩增,但其产物的表达对CA的近期预后无明显影响。
Objective: To investigate the expression of C-crb B-2 in genital condyloma acuminatum (CA) and its effect on the short-term prognosis of CA. Methods: The expression of C-erb B-2 in 39 CA lesions was examined by immunohistochemical SP method. The treatment of CA was followed up. Results: C-erb B-2 products were positive in 7 cases (17.95%) of 39 cases and negative in 32 cases (82.05%). Thirty-six patients were followed up for 6-14 months and were clinically cured. There was no significant difference in the number of recurrences between C-erb B-2 product and negative patients (P> 0.05). Conclusion: The activation and amplification of C gene in CA, but the expression of its product has no significant effect on the short-term prognosis of CA.