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现代辅助生殖技术(ART)中,子宫内膜容受性受损成为限制胚胎成功种植的重要因素之一。如何合理评价子宫内膜容受性一直是临床和基础研究关心的问题。本文主要综述目前用于评估子宫内膜容受性的临床指标,形态学、分子标志物,以及最新的蛋白组学评估方法,并分析其应用价值,以期提供更好、更客观和实时的子宫内膜容受性的评价指标,进而更加有的放矢地治疗不孕症患者,最大可能提高ART妊娠率。
In modern assisted reproductive technology (ART), impaired endometrial receptivity is one of the important factors that limit the successful implantation of embryos. How to reasonably evaluate endometrial receptivity has always been a concern in clinical and basic research. This review summarizes the current clinical indicators, morphological and molecular markers used to assess endometrial receptivity, as well as the latest proteomic evaluation methods and their value in application to provide better, more objective and real-time uterine Endometrial receptivity evaluation index, and then more targeted treatment of infertility patients, the maximum possible increase in ART pregnancy rate.