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目的:探讨血清β-人绒毛膜促性腺激素(β-HCG)、胎盘生长因子(PLGF)联合血管内皮生长因子(VEGF)水平在输卵管妊娠诊断鉴别中的价值。方法:收集我院于2014年1月~2015年1月间收治的输卵管妊娠患者50例作为观察组。另取同期在我院体检的正常宫内妊娠的孕妇50例作为对照组。采用酶联免疫法检测血清中VEGF、PLGF水平,采用放射免疫法检测血清中β-HCG水平,观察并比较两组患者血清VEGF、PLGF、β-HCG水平,计算灵敏度及特异度。结果:观察组血清β-HCG、PLGF水平低于对照组,VEGF水平高于对照组,差异均有统计学意义(均P<0.05)。血清β-HCG+PLGF+VEGF联合检测的灵敏度、特异度均较各单一指标检测高,差异均有统计学意义(P<0.05)。结论:通过β-HCG、PLGF联合VEGF检测方式可有效的提高诊断准确率。
Objective: To investigate the value of serum β-human chorionic gonadotropin (β-HCG), placental growth factor (PLGF) and vascular endothelial growth factor (VEGF) in differential diagnosis of tubal pregnancy. Methods: Fifty patients with tubal pregnancy who were treated in our hospital from January 2014 to January 2015 were collected as observation group. Another take the same period in our hospital physical examination of normal pregnant women, 50 cases of pregnant women as a control group. Serum levels of VEGF and PLGF were detected by enzyme-linked immunosorbent assay (ELISA). Β-HCG levels in serum were detected by radioimmunoassay. The levels of VEGF, PLGF and β-HCG in serum were observed and compared. The sensitivity and specificity were calculated. Results: Serum levels of β-HCG and PLGF in the observation group were lower than those in the control group, and VEGF levels were higher in the observation group than in the control group (all P <0.05). The sensitivity and specificity of the combined detection of serum β-HCG + PLGF + VEGF were higher than those of single indicators, the differences were statistically significant (P <0.05). Conclusion: The diagnostic accuracy of PLGF combined with VEGF can be effectively improved by β-HCG and VEGF.