目的评价高危型人乳头瘤病毒(HC2-HPV-DNA)联合超薄液基细胞学(TCT)检测在宫颈癌和癌前病变筛查中的诊断价值。方法对2013年1—7月在无锡妇幼保健院宫颈门诊已进行HPV及TCT检测的患者694例进行研究,同时做病理组织学活检。结果 HC2-HPV的阳性率随着宫颈病变严重程度的增加而升高,差异有统计学意义(P<0.05),HPV与TCT联合检测时,对于宫颈上皮内瘤变(CIN)Ⅰ及以上的病变诊断的敏感性为85.41%,较单独应用显著提高。结论 HC2-HPV联合TCT检测可以提高宫颈癌和癌前病变筛查的准确性。 Objective To evaluate the diagnostic value of high risk human papilloma virus (HC2-HPV-DNA) combined with ultra-thin liquid-based cytology (TCT) in the screening of cervical cancer and precancerous lesions. Methods From January to July 2013, 694 cases of HPV and TCT in cervical clinics of Wuxi MCH hospital were studied, and histopathological biopsy was performed at the same time. Results The positive rate of HC2-HPV increased with the severity of cervical lesions, the difference was statistically significant (P <0.05). When combined with HPV and TCT, the positive rate of HC2-HPV in cervical intraepithelial neoplasia (CIN) Ⅰ and above The sensitivity of pathological diagnosis was 85.41%, which was significantly higher than that of single application. Conclusion HC2-HPV combined with TCT can improve the accuracy of cervical cancer and precancerous lesions screening.