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采用大鼠为动物模型,考察了阿扑吗啡及其二酯衍生物口服吸收的差异,以及采用基于脂质的口服给药系统为载体时对大鼠口服吸收的影响。大鼠分为8组,分别为阿扑吗啡o/w型乳剂组、阿扑吗啡水性混悬液组、二月桂酰阿扑吗啡(DLA)o/w型乳剂组、DLA-单亚油酸甘油酯(Maisine 35-1)组、DLA-大豆油组、DLA自乳化给药系统(SEDDS)组、DLA w/o型乳
The rat model was used to investigate the differences in oral absorption of apomorphine and its diester derivatives and its effect on the oral absorption of rats when using the lipid-based oral delivery system as a carrier. Rats were divided into 8 groups: apomorphine o / w emulsion group, apomorphine aqueous suspension group, dilauroyl apomorphine (DLA) o / w emulsion group, DLA- (Maisine 35-1) group, DLA-soybean oil group, DLA self-emulsifying drug delivery system (SEDDS) group, DLA w / o type milk