The principles for lifecycle safety guarantee of engineering structures are proposed, and theconception is developed for developing the safety guarantee system by integrating the monitoringsystem, analysis system and maintenance system together on the basis of multi-sensor, distribu-tion-measurement, data fusion and digital-signal-processor (DSP) technologies as well asthree-dimensional (3D) fatigue fracture unified theory. As all the systems should work in situs and inreal-time, micromation and integration are important. Damage detectability is introduced to clarify therelationship of life prediction and healthy monitoring or faulty diagnosis. The research work to realizethe lifecycle safety guarantee system is summarized and perspectives for future efforts are outlined.