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目的观察奥美拉唑联合抗生素治疗萎缩性胃炎的治疗效果。方法选取医院收治的萎缩性胃炎患者80例,随机分为观察组和对照组各40例,观察组给予奥美拉唑、阿莫西林、呋喃唑酮等药物联合进行治疗,对照组给予奥美拉唑、阿莫西林、甲硝唑等药物联合进行治疗,观察2组患者的临床疗效和不良反应发生情况。结果治疗2个疗程后,观察组Hp转阴率明显高于对照组,差异有统计学意义(P<0.05);观察组总有效率为92.5%,对照组总有效率为85.0%。2组比较差异无统计学意义(P>0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对萎缩性胃炎患者采用奥美拉唑联合阿莫西林和呋喃唑酮进行治疗具有良好的临床疗效,能够有效清除Hp,且不良反应少,值得在临床上进一步推广。
Objective To observe the therapeutic effect of omeprazole combined with antibiotics on atrophic gastritis. Methods Eighty patients with atrophic gastritis treated in our hospital were randomly divided into observation group (40 cases) and control group (40 cases). The observation group was treated with omeprazole, amoxicillin and furazolidone. The control group was given omeprazole , Amoxicillin, metronidazole and other drugs were combined to treat the two groups of patients with clinical efficacy and adverse reactions. Results After 2 courses of treatment, the negative rate of Hp in the observation group was significantly higher than that in the control group (P <0.05). The total effective rate was 92.5% in the observation group and 85.0% in the control group. There was no significant difference between the two groups (P> 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The treatment of atrophic gastritis with omeprazole combined with amoxicillin and furazolidone has good clinical efficacy, can effectively remove Hp, and fewer adverse reactions, it is worth further promotion in the clinic.