代谢综合征(MS)与恶性肿瘤已经成为威胁全球性的健康问题。目前国外大量流行病学调查研究表明,MS患者恶性肿瘤(包括结直肠癌、子宫内膜癌、原发性肝癌等)的发病率明显增加。MS诱发恶性肿瘤的可能机制包括:长期高血糖的作用,肥胖和高血脂,胰岛素样生长因子的作用以及环境内分泌干扰物的作用等多方面因素协同作用。 Metabolic syndrome (MS) and malignancies have become a global health threat. At present, a large number of epidemiological studies abroad show that the incidence of MS patients with malignant tumors (including colorectal cancer, endometrial cancer, primary liver cancer, etc.) increased significantly. Possible mechanisms by which MS induces malignant tumors include the synergistic effects of long-term effects of hyperglycemia, obesity and hyperlipidemia, the role of insulin-like growth factor and the effects of environmental endocrine disruptors.