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目的探讨联合用药治疗老年消化性溃疡急性上消化道出血的临床效果。方法选择2010年3月~2013年4月山东省五莲县洪凝卫生院收治的102例老年消化性溃疡急性上消化道出血患者作为研究对象,随机将所有患者分为实验组和对照组(n=51)。实验组给予奥曲肽联合奥美拉唑治疗,奥美拉挫药量40 mg,奥曲肽药量0.1 mg,采用静脉注射方式治疗,对照组给予单一的奥美拉唑治疗,药量40 mg,通过与0.9%氯化钠注射液混合后进行静脉注射治疗,对比两组的临床疗效。结果实验组止血率效率、再出血量等明显高于对照组,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义。结论联合用药治疗老年人消化性溃疡急性上消化道出血相对于单一药物治疗效果更为显著,且安全性高,不良反应发生率较低。
Objective To investigate the clinical effects of combination therapy on acute upper gastrointestinal bleeding in patients with peptic ulcer. Methods From March 2010 to April 2013, 102 elderly patients with acute upper gastrointestinal bleeding from peptic ulcer admitted to Honglian Hospital of Wulian County, Shandong Province were selected as study subjects. All patients were randomly divided into experimental group and control group n = 51). The experimental group was treated with octreotide combined with omeprazole. Omeprazole was given in a dose of 40 mg and octreotide in a dose of 0.1 mg. The patients in the experimental group were treated with intravenous injection. The control group was given omeprazole alone. The dosage was 40 mg. 0.9% sodium chloride injection after intravenous injection, compared the clinical efficacy of the two groups. Results The hemostatic efficiency and rebleeding volume of the experimental group were significantly higher than those of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment. Conclusion Combined treatment of peptic ulcer acute upper gastrointestinal bleeding in the elderly compared with the single drug treatment effect is more significant, and the safety is high, the incidence of adverse reactions is low.