论文部分内容阅读
目的探讨米索前列醇防治产后出血致寒战不良反应的一般规律及其影响因素,为临床安全合理用药提供参考。方法收集本院产科应用米索前列醇防治剖宫产宫缩乏力性产后出血药品不良反应(ADR)报告进行用药分析研究,对纳入报告所涉及的患者年龄、体重、孕周、ADR既往史、用药剂量、给药途径、并用药品、ADR发生时间及转归进行总结分析。结果 (1)患者一般情况:本研究共纳入患者32例,年龄20~25岁4例,25~30岁10例,30~35岁15例,35~40岁3例,年龄最小22岁,最大40岁。各年龄组体重平均65.22 kg,孕周平均38+1周。(2)ADR既往史:32例报告中均明确记载无家族ADR史,既往有药物过敏史者4例,1例住院期间头孢唑林皮试阳性,其余27例无药物不良反应病史记载。(3)用药情况:32例报告中,30例舌下含服,2例直肠给药;29例单次用药,3例再次给药;用药剂量平均356.25μg。(4)合并用药:32例均合并其他宫缩剂,包括缩宫素注射液或卡前列甲酯栓或卡前列素氨丁三醇注射液,宫缩剂品种数平均2.47种。(5)ADR发生时间及转归:ADR出现时间最短15 min,最长100 min,平均58.28 min。32例ADR均给予地塞米松10 mg入壶,其中1例出现高热,30 min后再次给予地塞米松5 mg入壶后症状消失;无严重产后出血案例发生。结论临床医师和药师应重视米索前列醇引起寒战不良反应发生的影响因素,安全合理用药。
Objective To investigate the general rules and influential factors of misoprostol in preventing and treating adverse reactions caused by postpartum hemorrhage and provide references for clinical safe and rational drug use. Methods The obstetric application of misoprostol in the prevention and control of cesarean section in patients with uterine inertia postpartum hemorrhage adverse drug reaction (ADR) report for drug analysis study included in the report of patients involved in the age, weight, gestational age, previous history of ADR, Medication dose, route of administration, medication, ADR occurrence and outcome of the summary analysis. Results (1) The general situation of the patients: In this study, 32 patients were enrolled in this study. Among them, there were 4 patients aged 20-25 years, 10 cases 25-30 years old, 15 cases 30-35 years old, 3 cases 35- 40 years old and the youngest 22 years old. Up to 40 years old. The average body weight of 65.22 kg in each age group, an average of 38 + 1 weeks gestational age. (2) The past history of ADR: 32 cases reported clearly history of no family history of ADR, previous history of drug allergy in 4 cases, 1 case of cefazolin test during hospitalization, and the remaining 27 cases without history of adverse drug reactions records. (3) the use of drugs: 32 cases of reports, 30 sublingual, 2 rectum administration; 29 cases of single administration, 3 cases re-administration; the average dosage of 356.25μg. (4) combined medication: 32 cases were combined with other uterotonics, including oxytocin injection or card prepar methyl ester bolt or carboprost tromethamine injection, uterotonic agents an average of 2.47 species. (5) The time and outcome of ADR: ADR appeared the shortest 15 min, the longest 100 min, an average of 58.28 min. 32 cases of ADR were given dexamethasone 10 mg into the pot, of which 1 case of fever, 30 min after dexamethasone 5 mg into the kettle after the symptoms disappear; no serious postpartum hemorrhage occurred. Conclusion Clinicians and pharmacists should pay attention to the factors that cause misoprostol in misoprostol, safe and rational drug use.