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目的探讨冠心病患者血浆同型半胱氨酸(Hcy)、内皮素(ET)与冠状动脉病变的临床意义。方法选择心内科住院患者,经冠状动脉造影显示至少有1支血管病变狭窄≥50%入选为冠心病组(n=58),经冠状动脉造影显示正常为对照组(n=32),抽取空腹动脉和静脉血4ml分别测定Hcy和ET。结果冠心病患者血浆同型半胱氨酸、内皮素显著高于对照组(P<0.01),3支病变者血浆Hcy和ET显著高于单支病变者(P<0.001),动脉血与静脉血Hcy和ET比较差异无统计学意义(P>0.05)。结论冠心病患者血浆同型半胱氨酸、内皮素显著增高,血管病变支数越多,Hcy和ET增高越显著。血浆Hcy和ET增高可作为冠心病的独立危险因素之一。
Objective To investigate the clinical significance of plasma homocysteine (Hcy), endothelin (ET) and coronary artery disease in patients with coronary heart disease. Methods Inpatients with cardiology were enrolled. Coronary angiography showed that at least 1 vessel stenosis≥50% was selected as coronary heart disease group (n = 58). Coronary angiography showed normal control group (n = 32) Arterial and venous blood 4ml were measured Hcy and ET. Results The levels of plasma homocysteine and endothelin in patients with coronary heart disease were significantly higher than those in the control group (P <0.01). The plasma levels of Hcy and ET in the three lesions were significantly higher than those in the single vessel (P <0.001) There was no significant difference between Hcy and ET (P> 0.05). Conclusion Plasma homocysteine and endothelin are significantly increased in patients with coronary heart disease. The more vascular lesions, the more obvious the increase of Hcy and ET. Plasma Hcy and ET increased as coronary heart disease can be an independent risk factor.