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洛美沙星(LMLX)的特点是对大多数革兰氏阴性菌和某些革兰氏阳性菌以及结核分枝杆菌具有活性,生物利用度可达98%以上,可迅速透入组织和病灶,在肺泡巨噬细胞中的浓度超过组织和血药浓度20倍,半衰期长达8h,经尿排泄,在尿中浓度超过血药浓度100倍.为探讨LMLX治疗肺结核的疗效,对20名肺结核患者(年龄18～60岁,男18名,女2名),进行了LMLX疗效观察.浸润型、纤维空洞型和播放性肺结核分别为17、2和1例.全部患者均检出结核分枝杆菌,其中18例为耐药菌株.全部患者均有中毒症状,15名有发热、呼吸困难、频繁咳嗽、咳出粘稠的粘液脓性痰.肺部有罗音.血淋巴细胞减少,嗜中性粒细胞核型左移,血沉30～50mm/h,血蛋白含量异常.10名患者丙氨酸转氨酶(ALT)、天门冬酸转氨酶(AST)、γ-谷氨酸脱氢酶
LMLX is characterized by its activity on most Gram-negative bacteria and certain Gram-positive bacteria as well as Mycobacterium tuberculosis, with a bioavailability of over 98%, allowing rapid penetration into tissues and lesions, The concentration of alveolar macrophages than tissue and plasma concentration of 20 times the half-life of up to 8h, excreted by urine in the urine concentration than plasma concentration of 100 times.To explore the efficacy of LMLX treatment of tuberculosis, 20 patients with pulmonary tuberculosis (18 to 60 years old, 18 males and 2 females) were enrolled in this study.The curative effect of LMLX was observed.The infiltrates, fibrous cavities and broadcast tuberculosis were 17, 21 and 1 cases, respectively.Mycobacterium tuberculosis , Of which 18 were drug-resistant strains.All the patients had symptoms of poisoning, 15 had fever, difficulty breathing, frequent cough, and cough out viscous mucopurulent phlegm.The lungs had rales, blood lymphopenia, The neutrophil karyotype shifted to the left, the erythrocyte sedimentation rate was 30-50 mm / h, and the blood protein level was abnormal. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamate dehydrogenase