目前虽采用化疗药吡喹酮控制曼氏血吸虫感染,但考虑到吡喹酮的耐受性及耐药性问题,临床上仍须有新的治疗药物。蒿甲醚是抗疟药青蒿素的衍生物,能杀死日本血吸虫未成熟的虫卵,使感染率下降。实验研究表明它具有抗曼氏血吸虫感染的作用,本文报道了用蒿甲醚预防曼氏血吸虫感染的随机双盲对照试验。该实验在科特迪瓦西部的一个曼氏血吸虫病流行区进行,有354名学龄 Although the use of chemotherapy drugs praziquantel control Schistosoma mansoni infection, but taking into account the praziquantel resistance and drug resistance issues, the clinical still need new therapeutic drugs. Artemether is a derivative of artemisinin, an anti-malarial drug, that kills immature eggs of Schistosoma japonicum and reduces the rate of infection. Experimental studies have shown that it has the anti-Schistosoma mansoni infection effect, this paper reports the use of artemether to prevent Schistosoma mansoni infection randomized double-blind control trial. The experiment was conducted in a schistosoma mansoniosis endemic area in western Côte d’Ivoire with 354 school-age children