目前国内内镜检查常被认为是一次痛苦的经历,患者多有紧张、焦虑、恐惧和痛苦感,部分患者难以接受及惧怕再次检查.国外有较多研究报道有效的镇静药物在内镜检查中的应用,对解除患者的紧张、焦虑、恐惧和痛苦感有明显效果.但国内报道尚少.我院近期采用异丙酚和咪唑安定联合应用于部分内镜检查患者,以探讨其镇静效果和安全性. At present, endoscopic examination is often considered a painful experience in many patients with tension, anxiety, fear and pain, some patients are difficult to accept and fear of re-examination. There are more studies abroad reported effective sedative drugs in endoscopy Of the application, to relieve the patient’s tension, anxiety, fear and pain have a significant effect.However, the domestic reports are still less.Our hospital recently with propofol and midazolam combined with partial endoscopy in patients with sedation to explore and safety.