Heavy-ion irradiation is commonly used to study radiation damage of high level radioactive waste (HLW)forms, but S ion was never used before. In this investigation, 100 MeV 32S ions produced by tandem accelerator was used to study radiation effects on pyrochlore-rich synroc which contained simulated actinides. The amorphization and amorphous doses were determined by X-ray diffractometer (XRD) and transmission electron microscopy/select area electron diffraction (TEM/SAED). The vacancy defects induced by heavy-ion irradiation were characterized by using positron annihilation technique (PAT). The experimental results show that the amorphous dose is 0.5 dpa, the defects produced by heavy-ion irradiation are mainly voids, and irradiation could continue to intensify the vacancy defects even after the amorphous dose was reached.