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肿瘤早期的淋巴道转移是恶性肿瘤患者高死亡率的主要原因,其机制复杂,一直是肿瘤研究的难点.肿瘤淋巴道转移特异性蛋白标记物的发现有助于揭示恶性肿瘤早期发病机制、早期临床诊断和治疗.本文综述了近年来肝癌、胃癌、食管癌、结肠癌、乳腺癌、肺癌、鼻咽癌和前列腺癌淋巴道转移研究所取得的蛋白质组学成果,并对发现的与以上几种肿瘤淋巴道转移相关的蛋白标记物及其在肿瘤的发生、浸润、转移及病人预后中作用及机制进行了探讨.
The early lymphatic metastasis of cancer is the main reason of high mortality in patients with malignant tumors, the mechanism of which is complicated and has been a difficult point for tumor research.It is helpful to reveal the early pathogenesis of malignant tumors in early stage Clinical diagnosis and treatment.The paper summarizes the proteomics achievements of liver cancer, gastric cancer, esophageal cancer, colon cancer, breast cancer, lung cancer, nasopharyngeal carcinoma and prostate cancer lymph node metastasis in recent years, Which is a kind of protein marker related to tumor lymphatic metastasis and its role in tumorigenesis, invasion, metastasis and prognosis of patients.