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本文综述超ＭＩＣ抗菌药物作用后在体内产生多重效应以及其影响因素。根据近年来的国内外rrrrrrrrn文献报道，超ＭＩＣ抗菌药物作用后，细菌的形态结构、表面抗原性等超微结构发生变化，并且其对上皮细胞的rrrrrrrrn吸附力和毒力下降、而在细菌由非致死性损伤恢复至正常机能状态的过程中，亚最小抑菌浓度的抗菌药物虽rrrrrrrrn然不升高杀菌率，但显著延长细菌的生长抑制时间。细菌形态学的变化不仅减少其对机体的损害，而且增强rrrrrrrrn了机体免疫系统抗感染的能力；亚最小抑菌浓度效应符合机体对药物消除的特点，在治疗学中具有重要意义。rrrrrrrrn但体内抗菌药物作用后多重效应受到机体对药物的处置和病灶的病理生理环境等因素的影响，此项研究已rrrrrrrrn成为临床药学重要内容之一。
This review summarizes the multiple effects and their influencing factors in vivo after the action of ultra MIC antimicrobial agents. According to reports from domestic and foreign literatures in recent years, ultrastructural changes such as morphological structure and surface antigenicity of bacteria have been observed after the action of the ultra-MIC antibacterial agent, and Its ability to adsorb and reduce virulence in epithelial cells, while in the process of bacterial recovery from normal to non-lethal damage, submaximal Although the concentration of antibacterial drugs did not increase the rate of bactericidal, but significantly extended the growth of bacterial inhibition time. Bacterial morphological changes not only reduce their damage to the body, but also enhance the ability of the body’s immune system to fight infection; sub-minimum inhibitory concentration effect in line with the body The characteristics of elimination of drugs in the treatment of learning is of great significance. However, the multiple effects of antimicrobial agents after the body by the body of the drug treatment and pathophysiological environment and other factors, this study has r r r r r r r r n become one of the important contents of clinical pharmacy.